Palbociclib patient information macmillan. Palbociclib, a reversible and selective inhibitor of cyclin-dependent kinase (CDK) 4 and 6, is an antineoplastic agent. Palbociclib is given together with letrozole or fulvestrant, or inavolisib and fulvestrant. Jan 28, 2026 · On the basis of preclinical and clinical data, the addition of palbociclib (a selective inhibitor of cyclin-dependent kinases 4 and 6) may overcome resistance to both endocrine and HER2-directed What is palbociclib, and what is it used for? Palbociclib is a chemotherapy drug used to treat HER2-negative and HR-positive breast cancers in women and men, which are advanced or have spread to other organs (metastatic), in combination with an anti-estrogenic drug. Palbociclib (Ibrance) with fulvestrant is available on the NHS. Read and follow the instructions carefully. Insufficient data are available in patients requiring haemodialysis to provide any dose adjustment recommendation in this patient population. 2 Information about palbociclib Marketing authorisation indication 2. Palbociclib: learn about side effects, dosage, special precautions, and more on MedlinePlus IBRANCE 125 mg hard capsules palbociclib Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Anemia was reported more frequently in patients ≥65 than in patients <65 years of age treated with palbociclib plus letrozole, whereas similar incidences were reported in both age groups for patients treated with palbociclib plus fulvestrant (see 7. You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider. Palbociclib can cause fetal harm and male infertility. It belongs to a group of drugs called CDK (cyclin dependent kinase) inhibitors. Then 4 yrs ago I was diagnoised with secondary Breast cancer, I was taking Palbociclib alongside Anastezol and monthly demosumab injections. Your doctor will prescribe it for you if it has a proven benefit for your type of cancer. COMMON BRAND NAME (S Taking palbociclib as instructed is important to allow your treatment to be as effective as possible, so here are some key points to remember. Your doctor or nurse clinician has prescribed for you a treatment called palbociclib. Median duration of severe neutropenia was seven days and most patients had their palbociclib dose reduced or held. Myelosuppression/Infection • Advise patients to immediately report any signs or symptoms of myelosuppression or infection, such medication page for healthcare professionals to search for scientific information on Palbociclib is used in combination with hormonal therapy. Palbociclib, sold under the brand name Ibrance among others, is a medication developed by Pfizer for the treatment of HR-positive and HER2 -negative breast cancer. It is important that you take each medicine at the right time. If you can, avoid people with infections. This will either be an injection (called fulvestrant) or a tablet (called an aromatase inhibitor e. It works by blocking a protein that causes cancer cells to grow and multiply. Additional Information From Chemocare. Your cancer team will talk to you about this treatment and its possible side effects before you agree (consent) to have treatment. No dose adjustment of palbociclib is required for patients with mild, moderate or severe renal impairment (creatinine clearance greater than or equal to 15 mL/min). Palbociclib works by blocking the activity of proteins called CDK4 and CDK6 that control how fast cells grow. Feb 1, 2026 · This medicine comes with a patient information insert. It is best to read this information with our information about breast cancer. Feb 1, 2026 · Palbociclib can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. Find out how you have it, possible side effects and other important information. Palbociclib is used in combination with another medication as an initial treatment for a certain type of hormone receptor–positive, advanced breast cancer (breast cancer that depends on hormones such as estrogen to grow) that has spread to other parts of the body. Palbociclib is a chemotherapy drug used to treat HER2-negative and HR-positive breast cancers in women and men. You will have a routine blood test when you come into outpatients for your capsules. Blocking these proteins may slow or stop the growth of cancer cells. The treatment is given every four weeks. Common side effects of palbociclib include blood disorders, infections, fatigue, weakness (asthenia), high temperature (pyrexia), nausea, vomiting, diarrhea, oral inflammation (stomatitis), decreased appetite, increase in liver I was on Palbociclib form about 3 yr, having had primary breast cancer in 1994, has a mastecomy alo in 1994, followed by 10 yrs on Tazmoxifen. IBRANCE 75 mg film-coated tablets - Patient Information Leaflet (PIL) by Pfizer Limited Evidence-based recommendations on palbociclib (Ibrance) as initial endocrine-based therapy for hormone-receptor positive, human epidermal growth factor receptor 2 (HER2)‑negative, locally advanced or metastatic (secondary) breast cancer in adults. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. 1. Oct 7, 2024 · Palbociclib may be used to treat HR-positive, HER2-negative advanced or metastatic breast cancer in adults. This guide represents a brief summary of the medication derived from information Palbociclib, sold under the brand name Ibrance among others, is a medication developed by Pfizer for the treatment of HR-positive and HER2 -negative breast cancer. This helps to slow or stop the spread of cancer cells. com About Palbociclib Self-Care Tips: Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise. These tests will be taken as follows: Palbociclib (Ibrance) is a targeted cancer drug treatment for breast cancer. Palbociclib belongs to a group of targeted therapy drugs known as cancer growth inhibitors. anastrozole or letrozole). Patients should instead resume Palbociclib at the next planned treatment cycle. 4 Geriatrics). (NCODA), and Oncology Nursing Society (ONS) have collaborated in gathering information for and developing this patient education guide. I’m trying to find out how others have been doing on it. Each cycle consists of: Palbociclib 125mg capsule daily for 21 days then a 7 day break. It treats breast cancer, which occurs when cells in your breast grow and divide in an uncontrolled way. We are developing guidance on palbociclib with ive recently been diagnosed with stage 4 lung cancer. How long should I expect to start getting side affects, and what are others most common side affects. it came as a massive shock to me. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. The IBRANCE® Patient IBRANCE® is indicated for the treatment of patients with HR+/HER2− locally advanced or metastatic breast cancer and is suitable for pre-, peri- or postmenopausal women. . Its brand name is Ibrance. It is a possible treatment for advanced or metastatic breast cancer in adults if: their cancer is hormone receptor-positive and HER2-negative they have already had endocrine therapy exemestane plus everolimus is the most appropriate alternative to a CDK4/6 inhibitor. Palbociclib is a targeted or biological therapy drug. Myelosuppression/Infection - • Advise patients to immediately report any signs or symptoms of Important notice: The Association of Community Cancer Centers (ACCC), Hematology/Oncology Pharmacy Association (HOPA), National Community Oncology Dispensing Association, Inc. What is this medication? PALBOCICLIB (PAL boe SYE klib) treats breast cancer. Palbociclib stops cancer cells from growing. Patients requiring more than 2 dose reductions should be considered for discontinuation from Palbociclib treatment. It is best to read this information with our information about breast cancer. No dose reductions are required for letrozole due to myelosuppression. 1 Palbociclib (Ibrance, Pfizer) is indicated 'for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer: Neutropenia was the most frequently reported adverse effect of palbociclib with a median onset of 15 days for any grade and 28 days for NCI-CTC grade 3 or 4. g. When used to treat breast cancer, palbociclib is taken alongside hormone (endocrine) therapy. IBRANCE® tablets (palbociclib) Patient Counseling Information 17 PATIENT COUNSELING INFORMATION Advise the patient to read the FDA-approved patient labeling (Patient Information). This information from Lexicomp explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. Ask your doctor if you have any questions. Advise the patient to read the FDA-approved patient labeling (Patient Information). Palbociclib is the drug’s non-branded name. yesterday I started targeted therapy, Palbociclib 125mg and Letrozole. 7gi8u, yphbpt, hkh6, m58oa, jvacp, zy16n, vlvrp, 3fgx, qjuy, bt3kyy,